Fraunfelder F T, Meyer S M
Aust J Ophthalmol. 1984 Nov;12(4):391-4. doi: 10.1111/j.1442-9071.1984.tb01186.x.
The National Registry of Drug-induced Ocular Side Effects has accumulated 13 cases of possible major haemopoietic responses from topical ocular chloramphenicol. Over 75 cases of major haemopoietic events from carbonic anhydrase inhibitors are also reviewed. While numerous reports of local ocular effects secondary to timolol have been received by the Registry, the more significant adverse effects are the same systemic side effects seen with any beta-receptor blocking agent. Data in the Registry have shown that allopurinol may be possibly associated with cataract formation. Severe cardiovascular effects with elevated blood pressure and stroke are uncommon systemic adverse reactions following topical ophthalmic 10% phenylephrine, but these systemic effects have also been seen secondary to concentrations of 2.5%. Other drugs, such as adrenaline (epinephrine), ecothiopate (echothiophate), practolol, thiabendazole, and penicillamine are suspected of causing ocular pseudopemphigoid.
国家药物性眼部副作用登记处已积累了13例局部使用氯霉素可能引起的严重造血反应病例。同时还回顾了75多例碳酸酐酶抑制剂引起的严重造血事件。虽然登记处收到了大量关于噻吗洛尔继发局部眼部效应的报告，但更显著的不良反应是与任何β受体阻滞剂所见相同的全身副作用。登记处的数据表明，别嘌醇可能与白内障形成有关。局部使用10%去氧肾上腺素后，严重的心血管效应伴血压升高和中风是罕见的全身不良反应，但在2.5%的浓度下也有继发这些全身效应的情况。其他药物，如肾上腺素、依可碘酯、心得宁、噻苯达唑和青霉胺，被怀疑会引起眼部类天疱疮。
