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儿科眼部药物的安全性如何?

How safe are ocular drugs in pediatrics?

作者信息

Palmer E A

出版信息

Ophthalmology. 1986 Aug;93(8):1038-40. doi: 10.1016/s0161-6420(86)33624-8.

DOI:10.1016/s0161-6420(86)33624-8
PMID:3763151
Abstract

In comparison with that of adults, the smaller body mass of children raises questions of dosage. In addition, manifestations of ocular drug toxicity are different in some respects. The ocular drugs causing serious adverse ocular or systemic side effects in children include glaucoma medications, corticosteroids, phenylephrine, and the anticholinergic cycloplegics. The reported complications from using these medications in children will be briefly reviewed, and strategies for minimizing the risk of their adverse effects will be suggested, including a discussion of dosages and techniques of administration.

摘要

与成人相比,儿童较小的体重引发了剂量问题。此外,眼部药物毒性的表现在某些方面有所不同。在儿童中可引起严重眼部或全身副作用的眼部药物包括青光眼药物、皮质类固醇、去氧肾上腺素和抗胆碱能睫状肌麻痹剂。将简要回顾报道的儿童使用这些药物的并发症,并提出将其不良反应风险降至最低的策略,包括讨论剂量和给药技术。

相似文献

1
How safe are ocular drugs in pediatrics?儿科眼部药物的安全性如何?
Ophthalmology. 1986 Aug;93(8):1038-40. doi: 10.1016/s0161-6420(86)33624-8.
2
Systemic effects of eye drops.
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3
Ocular toxicology update.眼部毒理学最新进展。
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Systemic reactions to ophthalmic drug preparations.眼科药物制剂的全身反应。
Med Toxicol Adverse Drug Exp. 1987 Jul-Aug;2(4):287-93. doi: 10.1007/BF03259870.
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Trans Ophthalmol Soc U K (1962). 1974 Jul;94(2):487-95.
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Adverse reactions to topical ocular autonomic agents.眼部局部使用自主神经药物的不良反应。
J Am Optom Assoc. 1978 Jan;49(1):75-80.
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Mydriatic eye drops: severe adverse effects in children. Systemic reactions.散瞳眼药水:儿童中的严重不良反应。全身反应。
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Grand mal seizure in a child 30 minutes after Cyclogyl (cyclopentolate hydrochloride) and 10% Neo-Synephrine (phenylephrine hydrochloride) eye drops were instilled.在滴入赛克罗奇(盐酸环喷托酯)和10%新福林(盐酸去氧肾上腺素)眼药水30分钟后,一名儿童发生癫痫大发作。
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Fatal necrotising enterocolitis due to mydriatic eye drops.散瞳眼药水导致的致命性坏死性小肠结肠炎。
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Does astigmatism alter with cycloplegia?散光在睫状肌麻痹状态下会发生改变吗?
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Neurotoxic Effects of Topical Cyclopentolate.局部用环喷托酯的神经毒性作用。
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Adverse reactions following routine anticholinergic eye drops in a paediatric population: an observational cohort study.儿科人群使用常规抗胆碱能滴眼液后的不良反应:一项观察性队列研究。
BMJ Open. 2015 Dec 23;5(12):e008798. doi: 10.1136/bmjopen-2015-008798.
6
Pharmacologic management of glaucoma in childhood.儿童青光眼的药物治疗
Paediatr Drugs. 2007;9(2):71-9. doi: 10.2165/00148581-200709020-00001.
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[Depression of respiration via toxic effects on the central nervous system following use of topical brimonidine in an infant with congenital glaucoma].[先天性青光眼婴儿局部使用溴莫尼定后因对中枢神经系统的毒性作用导致呼吸抑制]
Ophthalmologe. 2007 Jun;104(6):505-7. doi: 10.1007/s00347-006-1471-z.
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Retinopathy of prematurity in VLBW and extreme LBW babies.极低出生体重儿和超低出生体重儿的早产儿视网膜病变
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Systemic effects of screening for retinopathy of prematurity.早产儿视网膜病变筛查的全身影响。
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Reduction in mydriatic drop size in premature infants.早产儿散瞳滴眼液尺寸的减小。
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