Perrot B, Clozel J P, de la Chaise A T, Cherrier F, Faivre G
Eur Heart J. 1984 Nov;5(11):883-9. doi: 10.1093/oxfordjournals.eurheartj.a061587.
The electrophysiological effects of prostacyclin (PGI2) were studied in 10 normal patients. Programmed stimulation was performed before and after infusion of 2.5, 5, 10 ng kg-1 min-1 of PGI2. Then, 0.2 mg kg-1 of propranolol was added to the higher dose of PGI2. We observed a net decrease of the systolic and diastolic arterial blood pressure beginning with the lowest dose. There was no effect on sinus node recovery time, atrial, His-Purkinje and ventricular effective refractory periods, AH and HV intervals. Atrioventricular (AV) nodal effective and functional refractory periods could be measured in 5 patients and were decreased in all cases. Sinus cycle length and anterograde and retrograde Wenckebach cycle lengths were significantly decreased by PGI2 in a dose dependent manner. The injection of propranolol increased all these values but did not suppress entirely the effects of PGI2. In conclusion, the electrophysiological effects of PGI2 were marked decreases of sinus cycle length and AV nodal refractoriness which may be partly related to enhanced sympathetic activity.
在10名正常患者中研究了前列环素（PGI2）的电生理效应。在输注2.5、5、10 ng·kg-1·min-1的PGI2之前和之后进行程控刺激。然后，将0.2 mg·kg-1的普萘洛尔添加到较高剂量的PGI2中。我们观察到从最低剂量开始，收缩压和舒张压出现净下降。对窦房结恢复时间、心房、希氏-浦肯野纤维和心室有效不应期、AH和HV间期无影响。在5名患者中可测量房室（AV）结有效和功能不应期，且在所有病例中均缩短。PGI2以剂量依赖性方式显著缩短窦性周期长度以及顺行和逆行文氏周期长度。注射普萘洛尔使所有这些值增加，但并未完全抑制PGI2的作用。总之，PGI2的电生理效应是窦性周期长度和房室结不应性显著降低，这可能部分与交感神经活动增强有关。
