Ghiglione M, Uttenthal L O, George S K, Bloom S R
Diabetologia. 1984 Dec;27(6):599-600. doi: 10.1007/BF00276976.
Although glucagon-like peptide-1 has the appearance of a glucagon-homologue that may be co-secreted with glucagon, synthetic glucagon-like peptide-1-(1-37) does not significantly affect plasma glucose and insulin concentrations when administered at high doses (100 and 400 micrograms) to cortisone-pretreated rabbits. This synthetic preparation thus lacks the primary metabolic effect of glucagon at the doses tested. An intra- or extra-pancreatic role of glucagon-like peptide-1 has yet to be discovered.
尽管胰高血糖素样肽-1看似是一种可能与胰高血糖素共同分泌的胰高血糖素同源物，但在给经可的松预处理的兔子高剂量（100和400微克）注射合成的胰高血糖素样肽-1-(1-37)时，它并不会显著影响血浆葡萄糖和胰岛素浓度。因此，这种合成制剂在所测试的剂量下缺乏胰高血糖素的主要代谢作用。胰高血糖素样肽-1在胰腺内或胰腺外的作用尚待发现。
