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Exon duplication and divergence in the human preproglucagon gene.

作者信息

Bell G I, Sanchez-Pescador R, Laybourn P J, Najarian R C

出版信息

Nature. 1983;304(5924):368-71. doi: 10.1038/304368a0.

DOI:10.1038/304368a0
PMID:6877358
Abstract
摘要

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Exon duplication and divergence in the human preproglucagon gene.人类前胰高血糖素原基因中的外显子重复与分化。
Nature. 1983;304(5924):368-71. doi: 10.1038/304368a0.
2
Hamster preproglucagon contains the sequence of glucagon and two related peptides.仓鼠前胰高血糖素原包含胰高血糖素的序列以及两种相关肽。
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Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence.豚鼠前胰高血糖素原基因的突变局限于激素原序列的特定部分。
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Molecular and cellular responses of islets during perturbations of glucose homeostasis determined by in situ hybridization histochemistry.通过原位杂交组织化学确定葡萄糖稳态扰动期间胰岛的分子和细胞反应。
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Effects of hypoglycemia and prolonged fasting on insulin and glucagon gene expression. Studies with in situ hybridization.低血糖和长期禁食对胰岛素和胰高血糖素基因表达的影响。原位杂交研究。
J Clin Invest. 1989 Aug;84(2):711-4. doi: 10.1172/JCI114219.
6
Pancreatic proglucagon processing: isolation and structures of glucagon and glucagon-like peptide from gene I.胰高血糖素原的加工：来自基因I的胰高血糖素和胰高血糖素样肽的分离与结构
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Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus.从一种新大陆啮齿动物八齿鼠（Octodon degus）中克隆编码胰岛淀粉样多肽、胰岛素和胰高血糖素前体的互补DNA。
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The glucagon superfamily: precursor structure and gene organization.胰高血糖素超家族：前体结构与基因组织
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Dinucleotide repeat polymorphism at the human preproglucagon gene.人胰高血糖素原基因的二核苷酸重复多态性
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Identical mRNA for preproglucagon in pancreas and gut.
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