川崎病中的淋巴细胞亚群

Lymphocyte subpopulations in Kawasaki disease.

作者信息

Shannon K, Fink C W, Buchanan G R, Punaro M, Stastny P

出版信息

Clin Exp Rheumatol. 1983 Jan-Mar;1(1):59-62.

Abstract

The relative percentages of subpopulations of peripheral T lymphocytes in children with Kawasaki Disease (KD) was investigated using matched antibodies directed against the T3, T4 and T8 antigens. The percentage of B cells was determined with antibodies against human surface immunoglobulins. Subjects were six children with acute KD who were compared to normal, age matched controls. The percentage of peripheral lymphocytes positive for OKT3 was 61% for KD children and 64% for controls; for OKT4 they were 41% and 44% respectively and for OKT8 both were 19%. The B cell percentages were 13% in KD and 11% in controls. Thus no abnormalities in the distribution of lymphocyte subtypes in children with KD was found. Previous studies of immune function in KD are reviewed.

摘要

利用针对T3、T4和T8抗原的匹配抗体，研究了川崎病（KD）患儿外周血T淋巴细胞亚群的相对百分比。用抗人表面免疫球蛋白抗体测定B细胞百分比。研究对象为6例急性KD患儿，并与年龄匹配的正常对照组进行比较。KD患儿外周血淋巴细胞OKT3阳性百分比为61%，对照组为64%；OKT4阳性百分比分别为41%和44%，OKT8阳性百分比在两组中均为19%。KD组B细胞百分比为13%，对照组为11%。因此，未发现KD患儿淋巴细胞亚群分布异常。本文回顾了以往关于KD免疫功能的研究。