Near normalization of metabolism of IDDM: comparison of continuous subcutaneous (CSII) versus intraperitoneal (CIPII) insulin delivery.

The effects of continuous insulin infusion given subcutaneously (CSII) and intraperitoneally (CIPII) on 24 h "metabolic" profile of four insulin dependent diabetic volunteers were assessed. When the insulin dose delivered is adjusted to achieve a near match of the peripheral plasma glucose profile, the 24 h profiles of free fatty acids, glycerol, lactate and beta-hydroxybutyrate and the hormones, insulin, glucagon, cortisol and catecholamines were identical. These results suggest that CIPII has no advantage over CSII in normalizing of the metabolism of the insulin dependent diabetic.