Longstaff E, Walker A I, Jäckh R
IARC Sci Publ. 1984(53):235-43.
A survey of the epidemiological and experimental evidence for nickel compound carcinogenesis suggests that nickel and nickel oxide should not be considered carcinogens for risk-assessment purposes. A rationalization of the observed experimental results from animal models using all exposure routes and based on differential solubilities in water and lipid has been proposed and explored in vitro with C3H10T1/2 cell-transformation studies. The results generated did not support this theory, but did support the argument that nickel and its oxide are noncarcinogenic. It is proposed that the IARC risk classification for nickel and nickel oxide should be modified accordingly.
