Messing R B, Flinchbaugh C, Waymire J C
Eur J Pharmacol. 1978 Mar 1;48(1):137-40. doi: 10.1016/0014-2999(78)90052-3.
Morphine induces naloxone-reversible increases of tryptophan and 5-hydroxyindoles in rat cerebral hemispheres, thalamus and cerebellum, but does not do so in striatum, hypothalamus, hippocampus and brain stem. Morphine also induces a rise in spinal cord 5-HIAA which is antagonized by naloxone, but there is no parallel change in tryptophan. Increases in brain 5-hydroxyindoles may be related to greater availability of tryptophan, but the elevation in spinal cord 5-HIAA appears to be unrelated to precursor availability.
吗啡可使大鼠大脑半球、丘脑和小脑中的色氨酸及5-羟吲哚含量产生纳洛酮可逆性增加，但在纹状体、下丘脑、海马和脑干中则不然。吗啡还可使脊髓5-羟吲哚乙酸（5-HIAA）含量升高，且该升高可被纳洛酮拮抗，但色氨酸含量并无相应变化。大脑中5-羟吲哚含量的增加可能与色氨酸可用性增加有关，但脊髓中5-HIAA含量的升高似乎与前体可用性无关。
