Turla R, Dordoni D, Falsetti L, Omodei U, Scagliola P
Acta Eur Fertil. 1984 Nov-Dec;15(6):445-8.
In this study the Authors have obtained an ovulatory response using intravenous Gn-RH treatment in four patients with hypothalamic hypogonadotropic amenorrhea. The Gn-RH was administered in a pulsatile manner with a small portable autoinfusion pump (Autosyringe, Inc., Hooksett). The ovarian follicular maturation, as it appears from the pelvic echography, was perfectly similar to that observed in a spontaneous ovulatory cycle. Endocrine picture by serial determination of gonadotropin; prolactin, estradiol and progesterone concentrations showed hormone values to be in the normal range. During the therapy no complications were observed; at the present time no pregnancy has occurred.
在本研究中，作者对4例下丘脑性低促性腺激素性闭经患者采用静脉注射Gn-RH治疗，获得了排卵反应。Gn-RH通过小型便携式自动输液泵（Autosyringe公司，胡克西特）以脉冲方式给药。盆腔超声显示的卵巢卵泡成熟情况与自然排卵周期中观察到的完全相似。通过连续测定促性腺激素、催乳素、雌二醇和孕酮浓度得到的内分泌情况显示激素值在正常范围内。治疗期间未观察到并发症；目前尚未发生妊娠。
