Mizunuma H, Obara M, Yamada K, Ibuki Y, Igarashi M
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Jun;38(6):933-9.
The effects of pulsatile LH-RH administration on ovulation induction and luteal phase activity were studied in 8 women with hypothalamic amenorrhea (2, with primary amenorrhea and 6 with secondary). Ten to 20 micrograms of LH-RH was subcutaneously injected by autoinfusion pump every 2 hours for more than 56 days. Six out of 8 women responded to the treatment and showed a total of 18 ovulatory cycles. The mean length of the follicular and luteal phases was 25.9 +/- 6.37 days and 11.9 +/- 0.43 days, respectively. The serum progesterone level in mid luteal phase was 12.0 +/- 2.35 ng/ml and was in the normal range for naturally cycling women. Two patients with secondary amenorrhea conceived in the 2nd and 3rd ovulatory cycle, respectively. In two patients who showed no response to LH-RH pulsatile administration for 56 days of treatment, serum LH and FSH levels were gradually lowered and the response to 100 micrograms of LH-RH iv injection was remarkably attenuated, suggesting that the pituitary gland was desensitized by the treatment.
对8名下丘脑性闭经女性（2例原发性闭经，6例继发性闭经）研究了脉冲式注射促黄体生成素释放激素（LH-RH）对诱导排卵及黄体期活性的影响。通过自动输液泵每2小时皮下注射10至20微克LH-RH，持续超过56天。8名女性中有6名对治疗有反应，共出现18个排卵周期。卵泡期和黄体期的平均长度分别为25.9±6.37天和11.9±0.43天。黄体中期血清孕酮水平为12.0±2.35纳克/毫升，处于自然月经周期女性的正常范围内。2例继发性闭经患者分别在第2个和第3个排卵周期受孕。在2例对LH-RH脉冲式给药56天治疗无反应的患者中，血清促黄体生成素（LH）和促卵泡生成素（FSH）水平逐渐降低，对静脉注射100微克LH-RH的反应明显减弱，提示垂体因该治疗而脱敏。
