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茶碱对心肌腺苷酸环化酶活性的影响。

Effect of theophylline on myocardial adenylate cyclase activity.

作者信息

Kruse E, Scholz H

出版信息

Experientia. 1978 Apr 15;34(4):504-5. doi: 10.1007/BF01935956.

DOI:10.1007/BF01935956
PMID:639951
Abstract

Theophylline (0.001-10.0 mM) did not increase but rather decrased adenylate cyclase activity (AC) of guinea-pig auricles. Isoprenaline (1-100 microgram) and sodium fluoride (0.3-10.0 mM) stimulated AC in a concentration-dependent manner.

摘要

茶碱（0.001 - 10.0毫摩尔）并未增加反而降低了豚鼠耳廓的腺苷酸环化酶活性（AC）。异丙肾上腺素（1 - 100微克）和氟化钠（0.3 - 10.0毫摩尔）以浓度依赖的方式刺激腺苷酸环化酶活性。

相似文献

1
Effect of theophylline on myocardial adenylate cyclase activity.茶碱对心肌腺苷酸环化酶活性的影响。
Experientia. 1978 Apr 15;34(4):504-5. doi: 10.1007/BF01935956.
2
Inhibition of rabbit cardiac adenylate cyclase by theophylline.茶碱对兔心脏腺苷酸环化酶的抑制作用。
J Pharm Pharmacol. 1985 Dec;37(12):924-6. doi: 10.1111/j.2042-7158.1985.tb05006.x.
3
Adenosine inhibition of catecholamine-stimulated cardiac membrane adenylate cyclase.腺苷对儿茶酚胺刺激的心肌膜腺苷酸环化酶的抑制作用。
Am J Physiol. 1985 May;248(5 Pt 2):H737-44. doi: 10.1152/ajpheart.1985.248.5.H737.
4
[Interrelation of the regulatory effects of adenosine, ATP and fluoride on heart adenylate cyclase].[腺苷、三磷酸腺苷和氟化物对心脏腺苷酸环化酶调节作用的相互关系]
Biokhimiia. 1982 Mar;47(3):455-64.
5
Divergent effects of theophylline on adenylate cyclase preparations from guinea-pig heart and lung.茶碱对豚鼠心脏和肺腺苷酸环化酶制剂的不同作用。
Experientia. 1971 Dec 15;27(12):1386. doi: 10.1007/BF02154243.
6
Adenylate cyclase and phosphodiesterase activity in rabbit ureter.
Invest Urol. 1977 Jul;15(1):15-8.
7
An antiadrenergic effect of adenosine on guinea-pig but not rabbit ventricles.腺苷对豚鼠心室有抗肾上腺素能作用，但对兔心室没有。
Eur J Pharmacol. 1987 May 7;137(1):67-75. doi: 10.1016/0014-2999(87)90183-x.
8
Selective block of cardiovascular adenylate cyclase activation in vivo.体内心血管腺苷酸环化酶激活的选择性阻断
J Pharm Pharmacol. 1977 Mar;29(3):184-6. doi: 10.1111/j.2042-7158.1977.tb11283.x.
9
Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain.茶碱对增加电刺激豚鼠心房中环磷酸腺苷（cAMP）水平及收缩力的效果。与异丙肾上腺素、钙及哇巴因的比较。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Dec;301(2):87-97. doi: 10.1007/BF00501422.
10
Alterations in beta-adrenergic stimulation of myocardial adenylate cyclase in endotoxic rats.内毒素血症大鼠心肌腺苷酸环化酶β-肾上腺素能刺激的变化
Am J Physiol. 1986 Mar;250(3 Pt 2):R358-64. doi: 10.1152/ajpregu.1986.250.3.R358.

引用本文的文献

1
Effects of adenosine and adenosine-analogs on adenylate cyclase activity in the rat adipocyte plasma membrane: comparison of the properties of the enzyme with Mn2+ and Mg2+ as divalent cations.腺苷及腺苷类似物对大鼠脂肪细胞质膜中腺苷酸环化酶活性的影响：以锰离子和镁离子作为二价阳离子时该酶性质的比较
Mol Cell Biochem. 1981 Oct 30;40(2):65-73. doi: 10.1007/BF00224749.
2
Effects of vanadate on the c-AMP system of the heart.
Basic Res Cardiol. 1980 May-Jun;75(3):438-43. doi: 10.1007/BF01908408.
3
Evidence for adenosine receptor-mediated isoprenaline-antagonistic effects of the adenosine analogs PIA and NECA on force of contraction in guinea-pig atrial and ventricular cardiac preparations.腺苷类似物PIA和NECA对豚鼠心房和心室心脏标本收缩力的腺苷受体介导的异丙肾上腺素拮抗作用的证据。

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Inhibition of norepinephrine stimulated adenyl cyclase by theophylline.茶碱对去甲肾上腺素刺激的腺苷酸环化酶的抑制作用。
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Preparation and characterization of adenylate cyclase from heart and skeletal muscle.心脏和骨骼肌中腺苷酸环化酶的制备与表征
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Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts.新型磷酸二酯酶抑制剂苯并咪唑衍生物阿迪苯旦（BM 14.478）在豚鼠心脏中的作用机制及强心活性
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Sensitive determination for adenylate cyclase activity by cyclic adenosine 3',5'-monophosphate protein binding assay.通过环磷酸腺苷蛋白结合测定法灵敏测定腺苷酸环化酶活性
Naunyn Schmiedebergs Arch Pharmacol. 1974;286(1):83-96. doi: 10.1007/BF00499106.
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Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides.环化和酰基取代对腺嘌呤核苷酸变力作用的影响。
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[Inhibition of adenyl cyclase preparations from rat kidney by calcium ions and various diuretics].[钙离子及多种利尿剂对大鼠肾腺苷酸环化酶制剂的抑制作用]
Naunyn Schmiedebergs Arch Pharmacol. 1972;273(3):248-66. doi: 10.1007/BF00501417.
7
Studies on the conditions for cyclic AMP formation in homogenised and intact fat cells by use of 3 H-ATP and 3 H-adenine.利用³H-ATP和³H-腺嘌呤对匀浆脂肪细胞和完整脂肪细胞中环磷酸腺苷（cAMP）形成条件的研究。
Pharmacology. 1971;6(2):109-25. doi: 10.1159/000136232.
8
A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
9
Glucagon-sensitive adenyl cylase in plasma membrane of hepatic parenchymal cells.肝实质细胞膜中对胰高血糖素敏感的腺苷酸环化酶。
Science. 1969 May 2;164(3879):566-7. doi: 10.1126/science.164.3879.566.
10
Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain.茶碱对增加电刺激豚鼠心房中环磷酸腺苷（cAMP）水平及收缩力的效果。与异丙肾上腺素、钙及哇巴因的比较。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Dec;301(2):87-97. doi: 10.1007/BF00501422.