Ommaya A K
Cancer Drug Deliv. 1984;1(2):169-79. doi: 10.1089/cdd.1984.1.169.
This is a review of implantable devices for chronic access and drug delivery to the central nervous system (CNS) via the cerebrospinal fluid, extracellular fluid, and vascular pathways. The current applications of such devices in the management of mycotic meningitis, meningeal leukemia and carcinomatosis, solid malignant tumors of the CNS, intractable cancer-associated pain, unresectable cystic tumors and in cytologic, pharmacologic, and experimental studies on the cerebrospinal fluid (CSF) are assessed. Specific attention is paid to the applications of the most commonly used device, a subcutaneous reservoir and pump (SRP), including its major uses and complications. A new system for local chemotherapy of malignant gliomas, the tumor cyst device (TCD), is also described.
这是一篇关于可植入装置的综述，这些装置用于通过脑脊液、细胞外液和血管途径实现对中枢神经系统（CNS）的长期通路建立及药物递送。评估了此类装置在霉菌性脑膜炎、脑膜白血病和癌病、中枢神经系统实体恶性肿瘤、难治性癌症相关疼痛、不可切除的囊性肿瘤管理中的当前应用，以及在脑脊液（CSF）的细胞学、药理学和实验研究中的应用。特别关注了最常用的装置——皮下贮液器和泵（SRP）的应用，包括其主要用途和并发症。还描述了一种用于恶性胶质瘤局部化疗的新系统——肿瘤囊肿装置（TCD）。
