Morris S E, Scarisbrick J J, Cameron E H, Groom G V, Buckingham M S, Everitt J, Elstein M
Fertil Steril. 1978 Mar;29(3):296-303. doi: 10.1016/s0015-0282(16)43156-0.
Two formulations of a low-dose oral contraceptive (Microgynon: 150 microgram of levonorgestrel [NG] +30 micrograms of ethynylestradiol [EE2]) were studied. The first was the "conventional" pill; the second was a "paper" pill prepared by evaporation of aliquots of a solution of the component steroids onto squares of edible cellulose separated by perforations, similar to a sheet of postage stamps. The effects of the two formulations on plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17beta-estradiol (E2), and progesterone were compared. Samples of blood were obtained from five women during a treatment period on the "conventional" pill and from five on the "paper" pill. When possible, blood samples were also obtained from a "control" cycle of each of these female subjects. Plasma LH, FSH, E2, and progesterone levels were determined by specific radioimmunoassay methods during control and treatment periods and NG and EE2 levels during treatment periods. Eight-hour plasma profiles for NG and EE2 at the beginning and in the later stage of the treatment periods were obtained and these samples were also analyzed for LH, FSH, E2, and progesterone. Results showed that with one exceptcrogynon were equally effective in suppressing ovulation. As in a previous study, FSH levels appeared to be one of the most sensitive indices of suppression.
对低剂量口服避孕药的两种制剂（妈富隆：150微克左炔诺孕酮[NG]+30微克乙炔雌二醇[EE2]）进行了研究。第一种是“传统”片剂；第二种是“纸片”片剂，它是通过将甾体激素成分的溶液等分蒸发到由穿孔隔开的可食用纤维素方块上制备的，类似于一张邮票。比较了这两种制剂对促卵泡激素（FSH）、黄体生成素（LH）、17β-雌二醇（E2）和孕酮血浆水平的影响。在服用“传统”片剂的治疗期间从五名女性身上采集血样，在服用“纸片”片剂的治疗期间从另外五名女性身上采集血样。只要有可能，还从这些女性受试者每人的一个“对照”周期采集血样。在对照期和治疗期通过特定放射免疫测定法测定血浆LH、FSH、E2和孕酮水平，在治疗期测定NG和EE2水平。获得了治疗期开始和后期NG和EE2的8小时血浆浓度曲线，并且还对这些样本进行了LH、FSH、E2和孕酮的分析。结果显示，除一种情况外，两种妈富隆制剂在抑制排卵方面同样有效。如先前一项研究中所示，FSH水平似乎是抑制作用最敏感的指标之一。
