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[儿茶酚胺给药后伤害性刺激及杏仁核复合体刺激引起的血流动力学变化]

[Hemodynamic changes upon nociceptive stimulation and stimulation of the amygdaloid complex following catecholamine administration].

作者信息

Isakova L S, Danilov G E

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Feb;64(2):191-9.

PMID:640085
Abstract

In cats, changes in arterial pressure (AP), intracardiac pressure (ICP), and blood flow volume rate following a nociceptive stimulus, stimulation of the amygdala and the combination of these before and after adrenaline (A) and norepinephrine (NE) administration into the lateral nucleus of amygdala, were studied. Nociceptive stimuli and electric stimulation of amygdala increased AP and ICP. The combination of these increased the pressor reaction. The blood flow volume rate was not altered by the nociceptive stimulus while decreasing at amygdalar stimulation. After A and NE administration the stimulation of amygdala plus the nociceptive stimulus suppressed the pressor reaction; a nociceptive stimulus was followed by the same changes as in intact cats; a nociceptive stimulus plus the stimulation of the amygdala increased the pressor reaction. The blood flow volume rate response to the stimuli was the same as in the control group. But the stimulation of amygdala after NE and a nociceptive stimulus plus amygdala stimulation (20 min after A) increased the blood flow volume rate, while the stimulation of amygdala alone with A administration reduced the blood flow.

摘要

研究了猫在伤害性刺激、杏仁核刺激以及在向杏仁核外侧核注射肾上腺素(A)和去甲肾上腺素(NE)前后这些刺激的组合作用下,动脉压(AP)、心内压(ICP)和血流量速率的变化。伤害性刺激和杏仁核的电刺激会升高AP和ICP。两者结合会增强升压反应。伤害性刺激不会改变血流量速率,而杏仁核刺激时血流量速率会降低。注射A和NE后,杏仁核刺激加伤害性刺激会抑制升压反应;伤害性刺激后的变化与未处理的猫相同;伤害性刺激加杏仁核刺激会增强升压反应。对刺激的血流量速率反应与对照组相同。但是,在注射NE后进行杏仁核刺激以及伤害性刺激加杏仁核刺激(注射A后20分钟)会增加血流量速率,而单独注射A进行杏仁核刺激会减少血流量。

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