Cini R, Sabat M, Sundaralingam M, Burla M C, Nunzi A, Polidori G, Zanazzi P F
Istituto di Chimica Generale dell'Università di Siena, Italy.
J Biomol Struct Dyn. 1983 Dec;1(3):633-7. doi: 10.1080/07391102.1983.10507470.
The X-ray structures of the isomorphous Mg2+, Ca2+, Mn2+ and Co2+ complexes of ATP have been determined. The metal ions are wrapped in hexa-coordination by the alpha, beta and gamma phosphate groups of two ATP molecules thus blocking the interaction of the metal ions with the adenine base. A second metal ion which is fully hydrated, M(H2O)2+(6), is engaged in a strong hydrogen bond with the gamma phosphate group of ATP and suggests a possible step in facilitating the cleavage between the beta and gamma phosphates in phosphoryl transfer reactions.
已测定了ATP的同晶型Mg2+、Ca2+、Mn2+和Co2+配合物的X射线结构。金属离子被两个ATP分子的α、β和γ磷酸基团以六配位方式包裹，从而阻断了金属离子与腺嘌呤碱基的相互作用。第二个完全水合的金属离子M(H2O)2+(6)与ATP的γ磷酸基团形成强氢键，这表明在磷酸转移反应中促进β和γ磷酸之间的裂解可能是一个步骤。
