Zenthon J, Adinolfi M, Polani P E
Paediatric Research Unit, Prince Philip Research Laboratories, Guy's Hospital Medical School, London, England.
Exp Clin Immunogenet. 1984;1(3):152-7.
The delayed-type hypersensitivity (DTH) response to the H-Y antigen was investigated in female mice which had been pre-treated with soluble or insoluble H-Y antigen. The present results suggest that Sertoli cells, cultured in vitro, release a factor which, if highly soluble, induces tolerance to male spleen cells. Mice showing marked DTH produced high titre H-Y antibodies after further injections of spleen cells from syngeneic males.
在预先用可溶性或不溶性H-Y抗原处理过的雌性小鼠中，研究了对H-Y抗原的迟发型超敏反应（DTH）。目前的结果表明，体外培养的支持细胞释放一种因子，如果该因子高度可溶，则会诱导对雄性脾细胞的耐受性。表现出明显DTH的小鼠在进一步注射同基因雄性的脾细胞后产生了高滴度的H-Y抗体。
