犬MHC I类抗原包含β2-微球蛋白。
Dog MHC class I antigens contain beta 2-microglobulin.
作者信息
van der Feltz M J, van der Korput H A, Giphart M J, Westbroek D L
机构信息
Laboratory for Experimental Surgery, Erasmus University, Rotterdam, The Netherlands.
出版信息
Exp Clin Immunogenet. 1984;1(1):56-9.
Detergent-solubilized DLA class I antigens have been isolated by immunoprecipitation from peripheral blood lymphocytes with an anti-beta 2-microglobulin serum and an alloantiserum. Amino acid composition and NH2-terminal amino acid sequence analysis confirmed that the DLA light chain is identical to dog urinary beta 2-microglobulin, and that the DLA heavy chain shows homology to the major histocompatibility complex class I heavy chains of other species.
通过用抗β2-微球蛋白血清和同种异体抗血清进行免疫沉淀，从外周血淋巴细胞中分离出了去污剂溶解的犬白细胞抗原（DLA）I类抗原。氨基酸组成和氨基末端氨基酸序列分析证实，DLA轻链与犬尿β2-微球蛋白相同，并且DLA重链与其他物种的主要组织相容性复合体I类重链具有同源性。
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