肺炎克雷伯菌质粒K21与强直性脊柱炎的病因无关。
Klebsiella plasmid K21 is not involved in the aetiology of ankylosing spondylitis.
作者信息
Ngo K Y, Rochu D, D'Ambrosio A M, Muller J Y, Lucotte G
机构信息
Laboratoire de Génétique Moléculaire, CNTS, Paris, France.
出版信息
Exp Clin Immunogenet. 1984;1(3):140-4.
PMID:6401143
Abstract
The possibility that a plasmid carried by Klebsiella pneumoniae plays a role in the pathogenesis of ankylosing spondylitis was explored. K. pneumoniae K21 contains a congruent to 25-kb plasmid, but this plasmid is not present in lymphocyte DNAs of ankylosing spondylitis HLA-B27 patients, as demonstrated by molecular hybridization experiments.
摘要
探讨了肺炎克雷伯菌携带的质粒在强直性脊柱炎发病机制中发挥作用的可能性。肺炎克雷伯菌K21含有一个约25kb的质粒，但分子杂交实验表明，该质粒不存在于强直性脊柱炎HLA - B27患者的淋巴细胞DNA中。
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