Hultborn R, Tveit E, Weiss L
Cancer Res. 1983 Jan;43(1):363-6.
Blood flow during "resting conditions" and during noradrenaline infusion were studied by the labeled microsphere technique in dimethylbenz(a)anthracene-induced mammary tumors, skin, muscle, and lung in the rat. Intratumoral distribution of flow was studied by autoradiography of spheres trapped in the vascular beds of the tumors. Histological examination was performed and correlated to the blood flow data. Mean blood flow to the tumors during "resting conditions" was relatively high (49 ml/min/100 g tissue) but was substantially decreased (5 ml/min/100 g tissue) during noradrenaline infusion which produced a pressure elevation of 35 mm Hg. Thus, vascular resistance of the tumor tissue increased dramatically. Cardiac output increased, but total systemic resistance was unchanged. Vascular resistance in muscle was unchanged in contrast to an increase seen in skin. Shunted systemic blood flow to the lungs and bronchial arterial flow decreased indicating reactivity of abnormally large arteriovenous passages in the tumors. Poorly differentiated tumors had a higher vascular resistance than did well-differentiated tumors. Autoradiography revealed a nodular flow distribution with a slight tendency of higher perfusion in the periphery of these tumors.
采用标记微球技术，对二甲基苯并(a)蒽诱导的大鼠乳腺肿瘤、皮肤、肌肉和肺在“静息状态”及去甲肾上腺素输注期间的血流情况进行了研究。通过对滞留在肿瘤血管床中的微球进行放射自显影，研究了肿瘤内的血流分布。进行了组织学检查，并将其与血流数据相关联。“静息状态”下肿瘤的平均血流相对较高（49毫升/分钟/100克组织），但在去甲肾上腺素输注期间显著降低（5毫升/分钟/100克组织），此时血压升高了35毫米汞柱。因此，肿瘤组织的血管阻力急剧增加。心输出量增加，但总全身阻力不变。与皮肤中血管阻力增加相反，肌肉中的血管阻力未发生变化。分流至肺部的全身血流量和支气管动脉血流量减少，表明肿瘤中异常大的动静脉通道具有反应性。低分化肿瘤的血管阻力高于高分化肿瘤。放射自显影显示血流呈结节状分布，在这些肿瘤的周边有稍高灌注的趋势。
