Stevenson F K, Stevenson G T, Tutt A L
J Exp Med. 1983 Jan 1;157(1):337-41. doi: 10.1084/jem.157.1.337.
An investigation has been made into the ability of human neoplastic B lymphocytes expressing surface IgM and IgD to export IgD in culture. Cells that expressed surface Ig of the lambda light chain type frequently exported IgD (10/12 patients), whereas cells expressing surface Ig of the kappa light chain type exported no IgD, although most (8/11 patients) were able to export IgM. It appears, therefore, that in most of the 23 cases studied, cells synthesizing IgD with lambda light chains can both express and export IgD, whereas those synthesizing IgD kappa can only insert it into the surface membrane. This finding and the known preponderance of lambda in plasma IgD imply that the possession of a lambda chain facilitates the IgD secretory pathway, a conclusion that implicates a control mechanism subsequent to the surface/secretory dichotomy arising from different splicings of heavy chain messenger RNA.
对表达表面IgM和IgD的人类肿瘤性B淋巴细胞在培养中输出IgD的能力进行了研究。表达λ轻链型表面Ig的细胞经常输出IgD（12例患者中有10例），而表达κ轻链型表面Ig的细胞不输出IgD，尽管大多数（11例患者中有8例）能够输出IgM。因此，在所研究的23例病例中的大多数似乎是，合成带有λ轻链的IgD的细胞既能表达又能输出IgD，而合成IgDκ的细胞只能将其插入表面膜。这一发现以及血浆IgD中λ的已知优势意味着拥有λ链有助于IgD分泌途径，这一结论暗示了在重链信使RNA不同剪接产生的表面/分泌二分法之后的一种控制机制。
