Mori S, Hagiwara S, Kodo H, Mohri N
Acta Pathol Jpn. 1986 Oct;36(10):1429-40.
Expression of IgD was studied immunopathologically on 50 cases of B cell lymphomas (B MLs), together with various B cell markers including IgM, kappa and lambda chains, B1, B2, (OK)B2, (OB)B7, (OK)T10, NUB1, Leu 1, Leu 14, and PCA. IgD was demonstrated on 19 cases heavily and on 8 weakly. It associated well with expression of two antigens, B2 (C3d receptor molecule) and Leu1 (pan-T antigen), besides IgM, while, B2 was closely related in expression on B MLs to (OK)B2, (OK)B7, and NUB1. lambda chain was dominant on IgD heavily-stained cases. Histopathologically, IgD positive MLs were distributed in various types. All of diffuse intermediate type were shown to be IgD positive (4/4, 3 heavily). As cases of this type were shown to express most of other B cell antigens present on non-tumorous primary follicle B cells or mantle zone B cells, this type of MLs is speculated to be a neoplastic counterpart of such non-tumorous B cells. Eight out of 18 cases of diffuse large cell type were IgD heavily positive, suggesting some unusual mechanisms in IgD expression on these neoplastic large cells, as non-tumorous B cells lose most of their surface IgD soon after blastoid transformation. Other types of MLs were discussed with special emphasis on expression of IgD.
对50例B细胞淋巴瘤（B MLs）进行免疫病理学研究，检测其IgD表达情况，并检测包括IgM、κ和λ链、B1、B2、(OK)B2、(OB)B7、(OK)T10、NUB1、Leu 1、Leu 14和PCA等多种B细胞标志物。19例显示IgD强阳性，8例弱阳性。除IgM外，它与两种抗原B2（C3d受体分子）和Leu1（泛T抗原）的表达密切相关，而B2在B MLs上的表达与(OK)B2、(OK)B7和NUB1密切相关。在IgD强染色的病例中，λ链占主导。组织病理学上，IgD阳性的MLs分布于各种类型。所有弥漫性中间型均显示IgD阳性（4/4，3例强阳性）。由于这种类型的病例显示表达非肿瘤性初级滤泡B细胞或套区B细胞上存在的大多数其他B细胞抗原，推测这种类型的MLs是此类非肿瘤性B细胞的肿瘤对应物。18例弥漫性大细胞型中有8例IgD强阳性，提示这些肿瘤性大细胞上IgD表达存在一些异常机制，因为非肿瘤性B细胞在母细胞样转化后很快会失去大部分表面IgD。对其他类型的MLs进行了讨论，特别强调了IgD的表达。
