Hunt J N
Am J Physiol. 1983 Jan;244(1):G89-94. doi: 10.1152/ajpgi.1983.244.1.G89.
The relative potencies of 47 compounds in slowing gastric emptying in one subject are given. The majority of the most effective compounds are detergent, but all detergents do not slow gastric emptying. It is proposed that the property common to those detergents that slow gastric emptying is the binding of ionized calcium. Disodium edetate (EDTA) is not a detergent. It has a high affinity for calcium, and it slows gastric emptying strongly. Reasons are given for proposing that decreasing the volumes of the lateral intercellular spaces of the luminal half of the duodenal villi mediates the slowing of gastric emptying by carbohydrate, protein, fats, and acids. Osmotic stimuli in the duodenal lumen, or in the enterocytes, reduce the flux of water into the lateral intercellular spaces. Anions of fatty acids and hydrogen ions displace calcium from a site on the tight junctions at the luminal border of the enterocytes. As a result, the tight junctions become more permeant to water and the lateral intercellular spaces shrink as their content drains into the duodenal lumen. Shrinking of the lateral intercellular space is proposed as the final common event in the transduction of the duodenal stimuli that slow gastric emptying.
给出了47种化合物在一名受试者中减缓胃排空的相对效力。大多数最有效的化合物是洗涤剂，但并非所有洗涤剂都会减缓胃排空。有人提出，那些能减缓胃排空的洗涤剂共有的特性是与离子化钙结合。依地酸二钠（EDTA）不是洗涤剂。它对钙有很高的亲和力，并且能强烈地减缓胃排空。文中给出了理由，认为减少十二指肠绒毛腔侧半部分细胞间间隙的体积介导了碳水化合物、蛋白质、脂肪和酸对胃排空的减缓作用。十二指肠腔内或肠细胞内的渗透刺激会减少水进入细胞间间隙的流量。脂肪酸阴离子和氢离子从肠细胞腔缘紧密连接处的一个位点取代钙。结果，紧密连接对水的渗透性增加，细胞间间隙侧随着其内容物排入十二指肠腔而缩小。细胞间间隙侧的缩小被认为是减缓胃排空的十二指肠刺激转导中的最终共同事件。
