近端胃迷走神经切断术与西咪替丁长期维持治疗慢性十二指肠溃疡：一项前瞻性随机试验。
Proximal gastric vagotomy versus long-term maintenance treatment with cimetidine for chronic duodenal ulcer: a prospective randomised trial.
作者信息
Gear M W
出版信息
Br Med J (Clin Res Ed). 1983 Jan 8;286(6359):98-9. doi: 10.1136/bmj.286.6359.98.
Abstract
Forty-four patients with chronic duodenal ulceration were allocated randomly to either long-term maintenance treatment with cimetidine or proximal gastric vagotomy. All were followed up both clinically and endoscopically for periods of one to four years. The rate of recurrence of ulcer during and after medical treatment was 54% while after surgery it was 10%. One patient developed severe allergic hepatitis while receiving maintenance treatment with cimetidine, and two others had to stop treatment because of possible drug reactions. Patients whose ulceration recurs while they are receiving treatment with cimetidine should be offered the possibility of operation.
摘要
44例慢性十二指肠溃疡患者被随机分为两组，一组接受西咪替丁长期维持治疗，另一组接受近端胃迷走神经切断术。所有患者均接受了为期1至4年的临床和内镜随访。药物治疗期间及治疗后的溃疡复发率为54%，而手术后的复发率为10%。1例患者在接受西咪替丁维持治疗时发生了严重的过敏性肝炎，另外2例患者因可能的药物反应而不得不停止治疗。接受西咪替丁治疗时溃疡复发的患者应考虑手术治疗。
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本文引用的文献
1
Intermittent treatment of duodenal ulcer with cimetidine.西咪替丁间歇治疗十二指肠溃疡。
Br Med J. 1980 Jul 5;281(6232):20-2. doi: 10.1136/bmj.281.6232.20.
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Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?西咪替丁治疗十二指肠溃疡，在溃疡初步愈合后继续用药，能否降低后续复发率？
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Operative mortality and postoperative morbidity of highly selective vagotomy.高选择性迷走神经切断术的手术死亡率和术后发病率。
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Br Med J. 1975 May 10;2(5966):301-3. doi: 10.1136/bmj.2.5966.301.
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Survival in peptic ulcer.消化性溃疡的生存率
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Prophylactic effect of cimetidine in duodenal ulcer disease.西咪替丁在十二指肠溃疡病中的预防作用。
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