Das C, Talwar G P
Fertil Steril. 1983 Feb;39(2):218-23.
Subcutaneous injections of luteinizing hormone-releasing hormone agonist D-Ser(But)6desGly10ProEA given to six pregnant baboons at 8-hour or 12-hour intervals over a period of 4 to 6 days around the time of the appearance of chorionic gonadotropin in the circulation diminished the plasma progesterone (P) to very low levels, leading to termination of pregnancy in all animals. The same amount of the agonist, given in a similar manner in the early luteal phase, although succeeding in reducing the plasma P levels by more than half, failed to abrogate pregnancy. The time and frequency of administration of the agonist appear to be important for interception of pregnancy.
在绒毛膜促性腺激素出现在循环中的时间前后4至6天内，以8小时或12小时的间隔对6只怀孕的狒狒进行皮下注射促黄体生成激素释放激素激动剂D-Ser(But)6desGly10ProEA，可使血浆孕酮（P）降至极低水平，导致所有动物终止妊娠。在黄体早期以类似方式给予相同剂量的激动剂，虽然成功地使血浆P水平降低了一半以上，但未能终止妊娠。激动剂的给药时间和频率似乎对终止妊娠很重要。
