Das C, Gupta S K, Talwar G P
J Steroid Biochem. 1985 Nov;23(5B):803-6. doi: 10.1016/s0022-4731(85)80018-2.
Until recently LHRH was believed to be a product of the hypothalamic origin whose primary function was to regulate the secretion of gonadotropin from the pituitary. In the last few years, a large body of experimental evidence has emerged for the existence of the releasing hormone at extrahypothalamic sites. The placenta is one such organ in which the hormone is made and probably has a role in stimulation of the secretion of chorionic gonadotropin as suggested by both in vivo and in vitro experiments. Superagonists of LHRH as well as monoclonal antibodies raised against the decapeptide administered during early pregnancy bring about a sharp decrease in blood chorionic gonadotropin and progesterone levels followed by termination of pregnancy in baboons. The mechanism of the abortifacient action appears to be curtailment of chorionic gonadotropin secretion by the placenta. Whether the immunointerception through LHRH antibodies will hold true for human beings also has to be investigated.
直到最近，促黄体生成素释放激素（LHRH）仍被认为是下丘脑来源的产物，其主要功能是调节垂体促性腺激素的分泌。在过去几年中，大量实验证据表明，在下丘脑外的部位也存在这种释放激素。胎盘就是这样一个器官，体内和体外实验均表明，胎盘能产生这种激素，并且可能在刺激绒毛膜促性腺激素的分泌中发挥作用。LHRH的超级激动剂以及针对十肽在妊娠早期给药所产生的单克隆抗体，会使狒狒血液中的绒毛膜促性腺激素和孕酮水平急剧下降，随后导致妊娠终止。这种堕胎作用的机制似乎是胎盘绒毛膜促性腺激素分泌减少。通过LHRH抗体进行免疫拦截对人类是否也适用，还有待研究。
