Carlson E
Infect Immun. 1983 Jan;39(1):193-7. doi: 10.1128/iai.39.1.193-197.1983.
Candida albicans has been shown to stimulate infection in mice by a number of bacteria. Mice inoculated intraperitoneally with as little as 500 colony-forming units of Staphylococcus aureus along with a nonlethal dose of 10(8) colony-forming units of C. albicans (one-third the dose causing 50% mortality in 7 days) developed widespread staphylococcal infection. S. aureus injected alone at that or considerably higher doses did not establish infection. Phage typing methods demonstrated that the staphylococcal infection was due to the bacterial organisms originally injected. A minimum dose of C. albicans between 1.1 X 10(5) and 1.1 X 10(7) colony-forming units was necessary for the amplification of virulence of S. aureus to take place. Serratia marcescens and Streptococcus faecalis inoculated intraperitoneally at small nonlethal doses could also be recovered from blood and tissues 5 days after animals were dually injected with C. albicans but not from animals which were inoculated with the same amounts of these bacteria alone.
白色念珠菌已被证明会被多种细菌刺激引发小鼠感染。腹腔注射低至500个金黄色葡萄球菌集落形成单位以及非致死剂量的10⁸个白色念珠菌集落形成单位（该剂量是7天内导致50%死亡率剂量的三分之一）的小鼠，会发生广泛的葡萄球菌感染。单独注射该剂量或更高剂量的金黄色葡萄球菌则不会引发感染。噬菌体分型方法表明，葡萄球菌感染是由最初注射的细菌引起的。白色念珠菌的最小剂量在1.1×10⁵至1.1×10⁷个集落形成单位之间，才会使金黄色葡萄球菌的毒力增强。腹腔注射小剂量非致死量的粘质沙雷氏菌和粪肠球菌，在动物同时注射白色念珠菌5天后，也能从血液和组织中分离出来，但单独注射相同数量这些细菌的动物则不会出现这种情况。
