慢性肾病中肾脏多巴胺对盐负荷反应的失败。
Failure of renal dopamine response to salt loading in chronic renal disease.
作者信息
Casson I F, Lee M R, Brownjohn A M, Parsons F M, Davison A M, Will E J, Clayden A D
出版信息
Br Med J (Clin Res Ed). 1983 Feb 12;286(6364):503-6. doi: 10.1136/bmj.286.6364.503.
Abstract
Eight patients with chronic glomerulonephritis and five age-matched normal volunteers were given additional sodium chloride by mouth under conditions of metabolic balance. Whereas in the normal volunteers plasma renin activity was suppressed and urinary excretion of free dopamine increased, in the patients dopamine was not mobilised and plasma renin activity was not completely suppressed. Abnormal retention of sodium and water in glomerulonephritis may be due partly to a failure to mobilise dopamine in the kidney. Specific renal dopamine agonists may be natriuretic and hypotensive in chronic glomerulonephritis.
摘要
八名慢性肾小球肾炎患者和五名年龄匹配的正常志愿者在代谢平衡条件下经口额外补充氯化钠。正常志愿者的血浆肾素活性受到抑制，尿中游离多巴胺排泄增加，而在患者中多巴胺未被调动，血浆肾素活性也未被完全抑制。肾小球肾炎中钠和水的异常潴留可能部分归因于肾脏中多巴胺未被调动。特异性肾多巴胺激动剂在慢性肾小球肾炎中可能具有利钠和降压作用。
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