多巴胺前体药物异波帕胺对正常受试者肾功能无影响。
Lack of effect of ibopamine, a dopamine pro-drug, on renal function in normal subjects.
作者信息
Harvey J N, Worth D P, Brown J, Lee M R
出版信息
Br J Clin Pharmacol. 1984 Jun;17(6):671-7. doi: 10.1111/j.1365-2125.1984.tb02402.x.
Abstract
The effects of two single oral doses of ibopamine (150 and 600 mg) on heart rate, blood pressure, urine flow, sodium, potassium and creatinine excretion were studied in normal volunteers. No significant change was observed in urine flow, sodium, potassium or creatinine excretion at either dose. No significant change was observed in heart rate or blood pressure except that systolic blood pressure was transiently elevated after the 600 mg dose (P less than 0.05).
摘要
在正常志愿者中研究了单次口服两剂异波帕胺（150毫克和600毫克）对心率、血压、尿流量、钠、钾和肌酐排泄的影响。两种剂量下，尿流量、钠、钾或肌酐排泄均未观察到显著变化。除600毫克剂量后收缩压短暂升高外（P小于0.05），心率或血压未观察到显著变化。
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