低氧性肺疾病继发红细胞增多症患者的红细胞单采术
Erythrapheresis in patients with polycythaemia secondary to hypoxic lung disease.
作者信息
Wedzicha J A, Rudd R M, Apps M C, Cotter F E, Newland A C, Empey D W
出版信息
Br Med J (Clin Res Ed). 1983 Feb 12;286(6364):511-4. doi: 10.1136/bmj.286.6364.511.
Abstract
Erythrapheresis was performed in 10 patients with polycythaemia secondary to hypoxic lung disease (mean PaO2, 6.8 kPa (51 mm Hg)). The mean packed cell volume decreased from 0.64 to 0.48 in men and from 0.56 to 0.42 in women, with significant decreases in blood viscosity at both high and low shear rates (p less than 0.001). Patients showed significant improvement in six-minute walking distances (p less than 0.001) and in tests of mental alertness (p less than 0.01) compared to control subjects. Visual analogue scales confirmed symptomatic improvement after erythrapheresis. Erythrapheresis significantly improved symptoms, mental function, and work performance in patients with polycythaemia secondary to hypoxic lung disease. The procedure was well tolerated by all patients and no complications occurred.
摘要
对10例继发于低氧性肺疾病的真性红细胞增多症患者（平均动脉血氧分压为6.8 kPa（51 mmHg））进行了红细胞单采术。男性的平均血细胞比容从0.64降至0.48，女性从0.56降至0.42，高低切变率下的血液黏度均显著降低（p<0.001）。与对照组相比，患者的6分钟步行距离（p<0.001）和精神警觉性测试（p<0.01）有显著改善。视觉模拟量表证实红细胞单采术后症状有所改善。红细胞单采术显著改善了继发于低氧性肺疾病的真性红细胞增多症患者的症状、心理功能和工作表现。所有患者对该操作耐受性良好，未发生并发症。
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