Effects of undernutrition in neonatal rats on physical development and food and water regulation.

The effects of neonatal undernutrition in rats on food and water regulation, external indices of development, and long-term regulatory behavior were investigated. Undernutrition produced retardation in some external indices of development. The ability to eat, drink, and maintain body weight at weaning were not seriously affected by the undernutrition. Longer term deficiencies in feeding efficiency, osmotic regulation, prandial drinking, and activity were found for experimental subjects. The involvement of peripheral-systemic factors as well as neurological retardation in producing feeding and drinking deficits following undernutrition are discussed.