McGahan M C, Chin B, Bentley P J
Exp Eye Res. 1983 Jan;36(1):67-73. doi: 10.1016/0014-4835(83)90090-8.
The (Mg) concentration in the rabbit lens is about 3.25 mmol/kg wet wt or 4.7 mM. This level is much greater than that in the bathing aqueous and vitreous humors. The Mg concentration in the peripheral part of this tissue is about four times greater than that in the inner 'nuclear' regions. Exchanges of Mg between the lens and its bathing fluids are very slow; under control conditions the lens appears to be virtually impermeable to Mg. Exposure to metabolic inhibitors, depolarizing concentrations of potassium, ouabain or replacement of Na with Li had little effect on the Mg content of the lens. Incubation of lenses in solutions containing EDTA or following freezing and thawing suggested that much of the Mg is present in a bound form. The ionophore A-23187 increased the permeability of the lens to Mg. Adjustment of the external Mg level in the presence of A-23187 indicated that the internal 'free' Mg concentration was about 3 mM. This result suggests that about 35% of the lenticular magnesium is bound.
兔晶状体中的镁（Mg）浓度约为3.25毫摩尔/千克湿重或4.7毫摩尔。这一水平远高于房水和玻璃体液中的浓度。该组织周边部分的镁浓度约为内部“核”区域的四倍。晶状体与其周围液体之间的镁交换非常缓慢；在对照条件下，晶状体似乎对镁几乎是不可渗透的。暴露于代谢抑制剂、去极化浓度的钾、哇巴因或用锂替代钠对晶状体的镁含量影响很小。在含有乙二胺四乙酸（EDTA）的溶液中孵育晶状体或经过冷冻和解冻后表明，大部分镁以结合形式存在。离子载体A - 23187增加了晶状体对镁的通透性。在A - 23187存在的情况下调整外部镁水平表明，内部“游离”镁浓度约为3毫摩尔。该结果表明约35%的晶状体镁是结合的。
