A simple radiometric in vitro assay for acetylcholinesterase inhibitors.
作者信息
Guilarte T R, Burns H D, Dannals R F, Wagner H N
出版信息
J Pharm Sci. 1983 Jan;72(1):90-2. doi: 10.1002/jps.2600720123.
PMID:6402586
Abstract
A radiometric method for screening acetylcholinesterase inhibitors has been described. The method is based on the production of [14C]carbon dioxide from the hydrolysis of acetylcholine. The inhibitory concentration at 50% (IC50) values for several known acetylcholinesterase inhibitors were in agreement with literature values. The new radiometric method is simple, inexpensive, and has the potential for automation.
摘要
Zotero 插件