Sternbach H A, Gold M S, Pottash A C, Extein I
JAMA. 1983 Mar 25;249(12):1618-20.
Forty-four consecutive outpatients referred to a psychiatric hospital for evaluation of depression and anergia were assessed by means of the protirelin (thyrotropin-releasing hormone) test. Nineteen patients (43%) had a blunted thyrotropin (TSH) response to protirelin, while six patients (13.5%) had augmented TSH responses indicating some degree of hypothyroidism. One patient had a low thyroxine level, while three patients had elevated basal TSH levels. Five of the six patients with augmented TSH responses were found to have antithyroid antibodies. These results suggest that a majority of depressed outpatients have abnormalities on the protirelin test and that the TSH response to protirelin is useful in both confirming a diagnosis of major depression and assessing thyroid status.
连续44名因抑郁和无活力而被转介到一家精神病医院进行评估的门诊患者接受了促甲状腺素释放激素试验。19名患者（43%）对促甲状腺素释放激素的促甲状腺素（TSH）反应迟钝，而6名患者（13.5%）的TSH反应增强，表明存在一定程度的甲状腺功能减退。1名患者甲状腺素水平低，3名患者基础TSH水平升高。6名TSH反应增强的患者中有5名被发现存在抗甲状腺抗体。这些结果表明，大多数抑郁门诊患者在促甲状腺素释放激素试验中存在异常，并且TSH对促甲状腺素释放激素的反应在确诊重度抑郁症和评估甲状腺状态方面均有用。
