口服葡萄糖会降低肝脏对胰岛素的摄取。
Oral glucose decreases hepatic extraction of insulin.
作者信息
Gibby O M, Hales C N
出版信息
Br Med J (Clin Res Ed). 1983 Mar 19;286(6369):921-3. doi: 10.1136/bmj.286.6369.921.
Abstract
Peripheral venous (plasma) insulin and C-peptide concentrations were measured in eight normal subjects given oral or intravenous glucose sufficient to produce similar plasma glucose concentrations. The expected increased insulin response to oral as compared with intravenous glucose was not matched by a comparable increase in C-peptide concentration. The ratio of insulin to C-peptide concentrations doubled 30 minutes after oral glucose was given; no comparable rise was seen with intravenous glucose (p = 0.01). This finding is interpreted as evidence for decreased hepatic extraction of insulin after administration of oral glucose. Such a decrease could account for at least half of the well known difference in peripheral insulin concentrations after administration of oral as compared with intravenous glucose.
摘要
在八名正常受试者中测量了外周静脉（血浆）胰岛素和C肽浓度，这些受试者口服或静脉注射了足以产生相似血浆葡萄糖浓度的葡萄糖。与静脉注射葡萄糖相比，口服葡萄糖后预期的胰岛素反应增加并未伴随着C肽浓度的相应增加。口服葡萄糖30分钟后，胰岛素与C肽浓度的比值增加了一倍；静脉注射葡萄糖时未观察到类似的升高（p = 0.01）。这一发现被解释为口服葡萄糖后肝脏对胰岛素摄取减少的证据。这种减少至少可以解释口服与静脉注射葡萄糖后外周胰岛素浓度众所周知的差异的一半。
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