Kashiwagi A, Fujita M, Usugane M, Taguchi T, Tanaka T
Gan. 1978 Feb;69(1):127-31.
Isozyme pattern of pyruvate kinase in the liver of nude mice bearing Ehrlich ascites tumor changed markedly during tumor growth. The change in isozyme pattern of pyruvate kinase was not due to infiltration or metastasis of tumor cells in the liver. Such a change in isozyme pattern of pyruvate kinase was also found in the liver of nude mice bearing canine gastric leiomyosarcoma induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), but not in the liver of nude mice bearing MNNG-induced canine gastric adenocarcinoma or human gastric adenocarcinoma.
携带艾氏腹水瘤的裸鼠肝脏中丙酮酸激酶的同工酶模式在肿瘤生长过程中发生了显著变化。丙酮酸激酶同工酶模式的变化并非由于肿瘤细胞在肝脏中的浸润或转移所致。在携带由N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的犬胃平滑肌肉瘤的裸鼠肝脏中也发现了丙酮酸激酶同工酶模式的这种变化，但在携带MNNG诱导的犬胃腺癌或人胃腺癌的裸鼠肝脏中未发现。
