Nespoli A, Chiara O, Clement M G, Dagnino G, Bevilacqua G, Aguggini G
Circ Shock. 1983;10(1):15-30.
The effects of octopamine on systemic and pulmonary circulation and on respiratory parameters have been studied in ten O2 100% breathing pigs. A rise in cardiac index (CI) due to an increase in the dynamics of the left ventricle and a progressive hypoxemia, notwithstanding the hyperventilation, was found. The decrease in arterial O2 tension was due to a rise in the pulmonary shunt fraction (QS/QT). The statistical analysis of cardiorespiratory parameters demonstrated that the high flow state linked with a non-Starling mechanism was the causing factor of a ventilation: perfusion ratio (VA/QT) decrease, which led to the rise in QS/QT. Also, a decrease in the lung compliance simultaneous to the increased blood flow was observed. It is suggested that octopamine may play a role in the pathogenesis of the cardiorespiratory hemodynamic impairment of cirrhosis and sepsis where high levels of this false neurotransmitter were observed.
在十只呼吸100%氧气的猪身上研究了章鱼胺对体循环和肺循环以及呼吸参数的影响。尽管存在过度通气，但发现由于左心室动力学增加导致心脏指数（CI）升高以及进行性低氧血症。动脉血氧张力降低是由于肺分流分数（QS/QT）升高所致。心肺参数的统计分析表明，与非斯塔林机制相关的高流量状态是通气/灌注比（VA/QT）降低的原因，这导致QS/QT升高。此外，还观察到随着血流增加肺顺应性降低。有人提出，章鱼胺可能在肝硬化和脓毒症的心肺血流动力学损害的发病机制中起作用，在这些疾病中观察到这种假神经递质水平升高。
