Villeneuve J P, Arsène D, Huet P M
Clin Invest Med. 1983;6(1):5-9.
The aminopyrine breath-test (ABT) has been proposed as a non-invasive quantitative test of liver function and reserve. To evaluate its usefulness, we compared the ABT with standard liver function tests, Child's classification of liver disease and ICG clearance, as means of assessing liver function in 30 patients with cirrhosis. The cumulative output of 14CO2 in breath during the 6 h following [14C]aminopyrine administration was significantly decreased in the cirrhotic group as compared with control subjects. The severity of liver dysfunction, as assessed by Child's classification, was associated with a progressive and statistically significant impairment of the ABT. There was a good correlation between the ABT and ICG systemic clearance (r = 0.770, P less than 0.001) and also between the ABT and ICG intrinsic clearance (r = 0.885, P less than 0.001), a measure which is independent of hepatic blood flow variations. These results further strengthen the concept that the ABT is a simple non-invasive method to assess quantitatively liver function and reserve, and could be useful in following the evolution of patients with liver disease.
氨基比林呼吸试验（ABT）已被提议作为一种肝功能及储备功能的非侵入性定量检测方法。为评估其效用，我们将ABT与标准肝功能检测、Child肝病分级以及吲哚氰绿（ICG）清除率进行了比较，以此作为评估30例肝硬化患者肝功能的手段。与对照组相比，肝硬化组在给予[14C]氨基比林后6小时内呼出气体中14CO2的累积排出量显著降低。根据Child分级评估的肝功能障碍严重程度与ABT的进行性且具有统计学意义的损害相关。ABT与ICG全身清除率之间存在良好的相关性（r = 0.770，P < 0.001），ABT与ICG固有清除率之间也存在良好相关性（r = 0.885，P < 0.001），后者是一种独立于肝血流变化的指标。这些结果进一步强化了这样一种观念，即ABT是一种评估肝功能及储备功能的简单非侵入性方法，并且可能有助于追踪肝病患者的病情进展。
