丙戊酰胺：部分性癫痫的对照试验。

Progabide: a controlled trial in partial epilepsy.

作者信息

Dam M, Gram L, Philbert A, Hansen B S, Lyon B B, Christensen J M, Angelo H R

出版信息

Epilepsia. 1983 Apr;24(2):127-34. doi: 10.1111/j.1528-1157.1983.tb04873.x.

DOI:10.1111/j.1528-1157.1983.tb04873.x

Abstract

Progabide (SL 76002) was studied in a randomized double-blind crossover trial using 20 outpatients suffering from partial complex seizures. Progabide was added to the concomitant antiepileptic treatment in a fixed dosage schedule. The design included an open therapy control unit. No significant difference was established between the number of partial seizures during treatment with progabide and placebo. A trend was observed for lower seizure frequency of secondary generalized seizures during treatment with progabide. Only mild and transient side effects were observed. There was no difference between the side effects of progabide and placebo.

摘要

在一项随机双盲交叉试验中，对20名患有部分性癫痫发作的门诊患者使用了丙戊酰胺（SL 76002）。丙戊酰胺以固定剂量方案添加到伴随的抗癫痫治疗中。该设计包括一个开放治疗对照组。在用丙戊酰胺治疗期间与安慰剂治疗期间，部分性癫痫发作的次数之间未发现显著差异。在丙戊酰胺治疗期间，观察到继发性全身性癫痫发作频率有降低的趋势。仅观察到轻微和短暂的副作用。丙戊酰胺和安慰剂的副作用之间没有差异。