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NK 细胞缺陷的米色小鼠体内针对实体瘤的自然细胞毒性细胞水平正常。

Normal levels of natural cytotoxic cells against solid tumours in NK-deficient beige mice.

作者信息

Stutman O, Cuttito M J

出版信息

Nature. 1981 Mar 19;290(5803):254-7. doi: 10.1038/290254a0.

Abstract

Natural cell-mediated cytotoxicity (NCMC) capable of in vitro lysis of various lymphoid and non-lymphoid tumours has been described in mice and other species, including man. NCMC has been proposed as a first level of defence against tumour growth in vivo, one which does not need the priming of the conventional immunological response. The effector cells of NCMC seem to belong to a special category of lymphoid cells, being neither classical T or B cells nor macrophages; natural killer (NK) cells have been proposed as the prototype effector cell, although some heterogeneity among effector cells seems to exist, depending on the target cells used for testing. Two main subgroups of NCMC effector cells have been defined: NK cells directed against lymphoma targets and natural cytotoxic (NC) cells directed against solid non-lymphoid tumours. We describe here another distinction between the two systems: while NK activity is low in mice homozygous for the beige (bg) gene NC activity in spleen cell preparations from these animals is comparable with that observed in the appropriate controls (bg/+ and +/+ littermates). The bg syndrome of mice affects lysosome, melanosome and enzymatic functions and is a homologue of the Chediak--Higashi syndrome of man. Defective NK activity in blood lymphocytes has also been reported in patients with Chediak--Higashi syndrome. We also show that several mouse strains which have low NK activity, have normal or high levels of NC functions, expanding our previous observation that NC and NK cells are under distinct genetic control.

摘要

在小鼠和包括人类在内的其他物种中,已经发现了能够在体外裂解各种淋巴样和非淋巴样肿瘤的天然细胞介导的细胞毒性(NCMC)。NCMC被认为是体内对抗肿瘤生长的第一道防线,这一防线不需要传统免疫反应的启动。NCMC的效应细胞似乎属于一类特殊的淋巴细胞,既不是经典的T细胞或B细胞,也不是巨噬细胞;尽管根据用于测试的靶细胞不同,效应细胞之间似乎存在一些异质性,但天然杀伤(NK)细胞已被认为是原型效应细胞。NCMC效应细胞主要分为两个亚组:针对淋巴瘤靶标的NK细胞和针对实体非淋巴样肿瘤的天然细胞毒性(NC)细胞。我们在此描述这两个系统之间的另一个区别:对于米色(bg)基因纯合的小鼠,NK活性较低,而这些动物脾细胞制剂中的NC活性与在适当对照(bg/+和+/+同窝小鼠)中观察到的活性相当。小鼠的bg综合征会影响溶酶体、黑素体和酶功能,是人类Chediak-Higashi综合征的同源物。也有报道称,Chediak-Higashi综合征患者的血液淋巴细胞中NK活性存在缺陷。我们还表明,几种NK活性较低的小鼠品系具有正常或高水平的NC功能,这扩展了我们之前的观察结果,即NC细胞和NK细胞受不同的基因控制。

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