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1
Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate.免疫系统中的独特型连接。I. 诱导产生的抗对氨基苯胂酸抗体及非特异性针对胂酸的内源性抗体上交叉反应独特型的表达。
J Exp Med. 1983 Apr 1;157(4):1116-36. doi: 10.1084/jem.157.4.1116.
2
Idiotype connectance in the immune system. II. A heavy chain variable region idiotope that dominates the antibody response to the p-azobenzenearsonate group is a minor idiotope in the response to trinitrophenyl group.免疫系统中的独特型连接。II. 一种在针对对氨基苯砷酸盐基团的抗体应答中占主导地位的重链可变区独特位，在针对三硝基苯基基团的应答中是次要独特位。
J Exp Med. 1985 Jan 1;161(1):53-71. doi: 10.1084/jem.161.1.53.
3
Regulation of the BALB/c anti-p-azophenylarsonate antibody response by monoclonal anti-idiotype. II. Idiotope expression in serum and its regulation.单克隆抗独特型对BALB/c抗对氨基苯砷酸盐抗体反应的调节。II. 血清中独特型表位的表达及其调节。
J Immunol. 1986 Jul 15;137(2):610-7.
4
Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.来自表达A/J品系主要交叉反应独特型的BALB/c小鼠的两种抗对氨基苯砷酸单克隆抗体的重链可变区的完整氨基酸序列。
J Exp Med. 1984 Oct 1;160(4):1070-86. doi: 10.1084/jem.160.4.1070.
5
Expression and regulation of two idiotype families and subsets within an idiotype family among BALB/c antibodies against p-azophenylarsonate.BALB/c小鼠抗对氨基苯砷酸抗体中两个独特型家族及一个独特型家族内各亚群的表达与调控
J Immunol. 1984 Jun;132(6):2715-23.
6
Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response.A/J抗偶氮苯砷酸盐反应中独特型抑制的精细特异性
J Exp Med. 1983 Feb 1;157(2):795-800. doi: 10.1084/jem.157.2.795.
7
A monoclonal anti-idiotope antibody reacting with a determinant of the cross-reactive idiotype on anti-p-azobenzenearsonate antibodies of A/J mice.一种单克隆抗独特型抗体，它与A/J小鼠抗对氨基苯砷酸盐抗体上交叉反应独特型的一个决定簇发生反应。
Aust J Exp Biol Med Sci. 1982 Aug;60 Pt 4:369-82. doi: 10.1038/icb.1982.41.
8
An intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of BALB/c mice.与BALB/c小鼠抗对氨基苯胂酸抗体相关的株内交叉反应独特型。
J Immunol. 1981 Apr;126(4):1263-7.
9
Use of JH4 joining segment gene by an anti-arsonate antibody that bears the major A-strain cross-reactive idiotype but displays diminished antigen binding.一种携带主要A株交叉反应独特型但抗原结合能力减弱的抗砷酸盐抗体对JH4连接片段基因的使用。
J Immunol. 1984 Jun;132(6):3164-71.
10
Selective activation by thymus-dependent antigens of distinct B cell subpopulations expressing a major cross-reactive idiotype.胸腺依赖性抗原对表达主要交叉反应独特型的不同B细胞亚群的选择性激活。
J Immunol. 1984 Oct;133(4):1801-10.

引用本文的文献

1
Immune Response Regulation by Antigen Receptors' Clone-Specific Nonself Parts.抗原受体克隆特异性非自身部分对免疫反应的调节
Front Immunol. 2018 Jun 25;9:1471. doi: 10.3389/fimmu.2018.01471. eCollection 2018.
2
Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region.转换重组和体细胞超突变由重链3'增强子区域控制。
J Exp Med. 2009 Nov 23;206(12):2613-23. doi: 10.1084/jem.20091280. Epub 2009 Nov 2.
3
A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling.一种新的单克隆抗体mAb 4A12，确定了RANTES的糖胺聚糖（GAG）结合域在抗HIV-1病毒效应和细胞内Ca2+信号传导中的作用。
J Exp Med. 1998 Nov 16;188(10):1917-27. doi: 10.1084/jem.188.10.1917.
4
Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysates.通过使用一种检测全细胞裂解物中mRNA序列的筛选技术来分离表达特定重链可变区基因片段的杂交瘤。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2470-4. doi: 10.1073/pnas.81.8.2470.
5
Non-dinitrophenyl-binding immunoglobulin that bears a dominant idiotype (Id460) associated with antidinitrophenyl antibody is specific for an antigen on Pasteurella pneumotropica.携带与抗二硝基苯基抗体相关的显性独特型（Id460）的非二硝基苯基结合免疫球蛋白对嗜肺巴斯德菌上的一种抗原具有特异性。
J Exp Med. 1984 Jan 1;159(1):221-33. doi: 10.1084/jem.159.1.221.
6
Idiotype profile of an immune response. II. Reversal of the relative dominance of major and minor cross-reactive idiotypes in arsonate-specific T-independent responses.免疫应答的独特型谱。II. 砷酸盐特异性非T细胞依赖性应答中主要和次要交叉反应性独特型相对优势的逆转
J Exp Med. 1983 Aug 1;158(2):438-51. doi: 10.1084/jem.158.2.438.
7
Production, isolation, and characterization of rabbit anti-idiotypic antibodies directed against human antithyrotrophin receptor antibodies.兔抗人抗促甲状腺素受体抗体独特型抗体的制备、分离及特性鉴定
J Clin Invest. 1984 Aug;74(2):488-95. doi: 10.1172/JCI111446.
8
A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.正常A/J小鼠的单个种系VH基因片段编码系统性红斑狼疮特征性自身抗体。
J Exp Med. 1986 Aug 1;164(2):614-26. doi: 10.1084/jem.164.2.614.
9
Parallel sets of autoantibodies in MRL-lpr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network.MRL-lpr/lpr小鼠中的平行自身抗体组。一种抗DNA、抗SmRNP、抗gp70网络。
J Exp Med. 1987 Feb 1;165(2):483-99. doi: 10.1084/jem.165.2.483.
10
Idiotype connectance in the immune system. II. A heavy chain variable region idiotope that dominates the antibody response to the p-azobenzenearsonate group is a minor idiotope in the response to trinitrophenyl group.免疫系统中的独特型连接。II. 一种在针对对氨基苯砷酸盐基团的抗体应答中占主导地位的重链可变区独特位，在针对三硝基苯基基团的应答中是次要独特位。
J Exp Med. 1985 Jan 1;161(1):53-71. doi: 10.1084/jem.161.1.53.

本文引用的文献

1
Rat immunoglobulins.大鼠免疫球蛋白。
Vet Immunol Immunopathol. 1979 Nov;1(1):61-78. doi: 10.1016/0165-2427(79)90008-4.
2
The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
Biochem J. 1959 Sep;73(1):119-26. doi: 10.1042/bj0730119.
3
RECONSTITUTION OF 7S MOLECULES FROM L AND H POLYPEPTIDE CHAINS OF ANTIBODIES AND GAMMA-GLOBULINS.由抗体和γ-球蛋白的L链和H链多肽链重构7S分子
J Exp Med. 1964 May 1;119(5):789-815. doi: 10.1084/jem.119.5.789.
4
Azoproteins. II. A spectrophotometric study of the coupling of diazotized arsanilic acid with proteins.偶氮蛋白。II. 重氮化对氨基苯胂酸与蛋白质偶联的分光光度研究。
J Biol Chem. 1960 Apr;235:1051-4.
5
Monoclonal anti-azobenzenearsonate antibodies expressing the cross-reactive idiotype: immunochemical studies show that all idiotypic determinants reside on a single molecule.表达交叉反应独特型的抗偶氮苯胂酸盐单克隆抗体：免疫化学研究表明，所有独特型决定簇都位于单个分子上。
Scand J Immunol. 1981;13(5):433-40. doi: 10.1111/j.1365-3083.1981.tb00153.x.
6
Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. III. Detection of Id-460 in normal serum that does not bind dinitrophenyl.独特型（Id - 460）在体内抗二硝基苯基抗体反应过程中的表达。III. 在不结合二硝基苯基的正常血清中检测Id - 460
J Exp Med. 1981 Nov 1;154(5):1442-54. doi: 10.1084/jem.154.5.1442.
7
Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones.独特型-抗独特型调节。I. 用结合果聚糖的骨髓瘤蛋白进行免疫会导致自身抗（抗独特型）抗体的出现以及沉默克隆的激活。
J Exp Med. 1981 Apr 1;153(4):951-67. doi: 10.1084/jem.153.4.951.
8
Degree of heterogeneity of binding specificities of antibodies to the phenylarsonate group that share a common idiotype.具有共同独特型的抗体与苯胂酸基团结合特异性的异质性程度。
Mol Immunol. 1982 Nov;19(11):1433-9. doi: 10.1016/0161-5890(82)90190-0.
9
The relation of idiotype expression to isotype and allotype in the anti-p-azobenzenearsonate response.抗对氨基苯砷酸反应中独特型表达与同种型和同种异型的关系。
Eur J Immunol. 1982 Mar;12(3):175-83. doi: 10.1002/eji.1830120302.
10
The strain A anti-p-azophenylarsonate major cross-reactive idiotypic family includes members with no reactivity toward p-azophenylarsonate.A品系抗对氨基苯砷酸盐主要交叉反应性独特型家族包括对对氨基苯砷酸盐无反应性的成员。
Eur J Immunol. 1981 Oct;11(10):832-9. doi: 10.1002/eji.1830111016.

免疫系统中的独特型连接。I. 诱导产生的抗对氨基苯胂酸抗体及非特异性针对胂酸的内源性抗体上交叉反应独特型的表达。

Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate.

作者信息

Hornbeck P V, Lewis G K

出版信息

J Exp Med. 1983 Apr 1;157(4):1116-36. doi: 10.1084/jem.157.4.1116.

DOI:10.1084/jem.157.4.1116
PMID:6403653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186990/
Abstract

A new cross-reactive idiotope family (CRIAD8) is described that contains subpopulations of antibodies binding to different epitopes. One subpopulation occurs naturally in normal sera from strain A mice, is found mainly on IgG2 and IgG3 subclasses, does not bind p-azobenzenearsonate (ABA)+, does not express CRI5Ci, and can be selectively stimulated by low doses of antiidiotype antibody (AD8). The second subpopulation is not found in normal serum, binds ABA, is found on all IgG subclasses, expresses CRI5Ci, and is selectively stimulated by ABA-conjugated proteins. Since CRIAD8 was found on both subpopulations of antibody, and since each subpopulation could be selectively expanded, it was possible to study the effect that expansion of the ABA- CRIAD8+ set had on subsequent responses elicited by ABA-keyhole limpet hemocyanin (KLH) in the ABA+ CRIAD8+ set. In these experiments, prior immunization with AD8 restricted the subsequent response of the ABA+ CRIAD8+ set to ABA-KLH. Furthermore, only those doses of AD8 that stimulated the ABA-CRIAD8+ set reduced the responsiveness of the ABA+ CRIAD8+ set to ABA-KLH, suggesting that the two phenomena are causally related. These findings argue that CRIAD8 correlates well with a regulatory idiotope and that immune responses by lymphocyte clones that have different antigen-binding specificities can affect one another as a result of their sharing such an idiotope. These results strongly favor a network organization of the immune system.

摘要

描述了一个新的交叉反应性独特型家族（CRIAD8），其包含与不同表位结合的抗体亚群。一个亚群天然存在于A系小鼠的正常血清中，主要存在于IgG2和IgG3亚类上，不结合对氨基苯砷酸盐（ABA）+，不表达CRI5Ci，并且可被低剂量的抗独特型抗体（AD8）选择性刺激。第二个亚群在正常血清中未发现，结合ABA，存在于所有IgG亚类上，表达CRI5Ci，并且被ABA偶联蛋白选择性刺激。由于在抗体的两个亚群上都发现了CRIAD8，并且由于每个亚群都可以被选择性扩增，因此有可能研究ABA-CRIAD8+组的扩增对ABA+CRIAD8+组中随后由ABA-钥孔戚血蓝蛋白（KLH）引发的反应的影响。在这些实验中，用AD8预先免疫限制了ABA+CRIAD8+组对ABA-KLH的后续反应。此外，只有那些刺激ABA-CRIAD8+组的AD8剂量降低了ABA+CRIAD8+组对ABA-KLH的反应性，这表明这两种现象存在因果关系。这些发现表明CRIAD8与一个调节性独特型密切相关，并且具有不同抗原结合特异性的淋巴细胞克隆的免疫反应由于共享这样一个独特型而可能相互影响。这些结果强烈支持免疫系统的网络组织。