A/J抗偶氮苯砷酸盐反应中独特型抑制的精细特异性
Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response.
作者信息
Rothstein T L, Margolies M N, Gefter M L, Marshak-Rothstein A
出版信息
J Exp Med. 1983 Feb 1;157(2):795-800. doi: 10.1084/jem.157.2.795.
Abstract
Two hapten-inhibitable murine monoclonal antiidiotopic antibodies identified two idiotopes expressed by the heavy chain of hybridoma protein 36-65, whose amino acid sequence is encoded in the germ line of A/J mice. Among cross-reactive idiotype-positive hybridoma proteins and p-azophenylarsonate-immune antibodies, the two idiotopes were not always expressed together; some diversified antibodies expressed one idiotope without the other. Suppression that was induced by the two antiidiotopes was idiotope specific and corresponded to the fine specificities of these two reagents.
摘要
两种可被半抗原抑制的小鼠单克隆抗独特型抗体鉴定出了由杂交瘤蛋白36-65重链所表达的两个独特型表位，该杂交瘤蛋白的氨基酸序列由A/J小鼠的种系编码。在交叉反应性独特型阳性杂交瘤蛋白和对氨基苯胂酸免疫抗体中，这两个独特型表位并不总是同时表达；一些多样化抗体只表达其中一个独特型表位。这两种抗独特型抗体所诱导的抑制是独特型特异性的，并且与这两种试剂的精细特异性相对应。
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本文引用的文献
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