Heinzl S
Geburtshilfe Frauenheilkd. 1978 Mar;38(3):220-6.
Results of 141 therapeutic abortions in the second trimestre of pregnancy with Prostaglandine E2 gel or Prostaglandine F2 alpha gel are reported. Some required oxytocin augmentation. There were 102 legal abortions. Five cases had medical indications, 97 cases had psychosocial indications. There were 39 cases of missed abortion or intra-uterine fetal death. Prostaglandine gel was developed in 1973 by Lippert. The Prostaglandine gel was administered by catheter into the extra-amniotic space. Of all 141 cases 136 (96.5%) aborted within 36 hours. The mean administration-abortion interval was 10 h 5 min-3 h 45 min in the group with Prostaglandine E2 gel and 10 h 4 min +/- 6 h 3 min in the group with Prostaglandine E2 gel augmented with Oxytocin. In the group with Prostaglandine F2 alpha gel the mean interval was 9 h 52 min +/- 6 h 50 min and in the group with Prostaglandine F2 alpha gel augmented with oxytocin the mean interval was 16 h 17 min +/- 8 h 19 min. The mean dosage of Prostaglandine corresponded to the mean administration abortion interval time. 1/3 of the cases had side effects. The method and it's result are compared with other series.
报告了141例在妊娠中期使用前列腺素E2凝胶或前列腺素F2α凝胶进行治疗性流产的结果。有些病例需要催产素加强宫缩。其中有102例合法流产。5例有医学指征，97例有社会心理指征。有39例稽留流产或宫内胎儿死亡。前列腺素凝胶由利珀特于1973年研制。通过导管将前列腺素凝胶注入羊膜外间隙。在所有141例病例中，136例（96.5%）在36小时内流产。使用前列腺素E2凝胶组的平均给药至流产间隔为10小时5分钟至3小时45分钟，使用前列腺素E2凝胶并加用催产素组的平均间隔为10小时4分钟±6小时3分钟。使用前列腺素F2α凝胶组的平均间隔为9小时52分钟±6小时50分钟，使用前列腺素F2α凝胶并加用催产素组的平均间隔为16小时17分钟±8小时19分钟。前列腺素的平均剂量与平均给药至流产间隔时间相对应。1/3的病例有副作用。将该方法及其结果与其他系列进行了比较。
