Wilson W B
Obstet Gynecol. 1978 Jun;51(6):699-701.
This study was undertaken to determine a method of amino infusion that would 1) produce abortion within 12 hours; 2) be relatively free from risks of coagulapathy and electrolyte imbalance; 3) not result in delivery of liveborns; and 4) incur minimal gastrointestinal side effects from prostaglandin. Patients were randomly assigned to 1 of 3 groups unless history and examination revealed a contraindication to the use of prostaglandin. Three infusions were used: prostaglandin alone, urea alone, and a combination of urea and prostaglandin. All patients had pre-infusion laminaria inserted and all received oxytocin following infusion. There was a significant difference in instillation to abortion time when comparing the three groups and a marked reduction in gastrointestinal side effects using a lower dosage of prostaglandin. The synergistic effect of urea and prostaglandin F2alpha, previously demonstrated was further enhanced by the use of oxytocin and laminaria. This produced a mean instillation to abortion time significantly shorter than previous studies have shown and, indeed, offers a means of second trimester abortion suitable for use in ambulatory surgery facilities, precluding the high cost of inpatient care.
本研究旨在确定一种氨基酸输注方法，该方法要能：1）在12小时内引发流产；2）相对无凝血病和电解质失衡风险；3）不会导致活产儿出生；4）因前列腺素产生的胃肠道副作用最小。除非病史和检查显示有使用前列腺素的禁忌证，否则患者被随机分配至3组中的1组。使用了三种输注方法：单独使用前列腺素、单独使用尿素以及尿素与前列腺素联合使用。所有患者在输注前均置入了海藻棒，且所有患者在输注后均接受了催产素治疗。比较三组时，滴注至流产的时间存在显著差异，且使用较低剂量的前列腺素时胃肠道副作用明显减少。先前已证明的尿素与前列腺素F2α的协同作用通过使用催产素和海藻棒得到了进一步增强。这使得滴注至流产的平均时间显著短于先前研究显示的时间，并且确实提供了一种适用于门诊手术设施的中期妊娠流产方法，避免了住院护理的高昂费用。
