Brame R G, MacKenna J
Am J Obstet Gynecol. 1983 Apr 15;145(8):992-1000. doi: 10.1016/0002-9378(83)90854-2.
Clinical utility of vaginal pool amniotic fluid assessment in premature rupture of the membranes was prospectively studied in 214 patients between July 1, 1978, and June 30, 1981. We used a policy of nonintervention in patients with premature rupture of the membranes prior to 36 weeks' gestation. Vaginal samples collected on admission and daily thereafter were analyzed for phospholipids. Patients underwent delivery for any one of these conditions: (1) presence of phosphatidylglycerol, (2) spontaneous labor, or (3) sepsis. One hundred sixty-seven patients had no phosphatidylglycerol initially. Thirty-six of these acquired phosphatidylglycerol, and none had respiratory distress syndrome. Eight patients underwent delivery because of signs of sepsis in the mother, but all infants of septic mothers survived. The newborn infants of 49 patients developed the respiratory distress syndrome, and among these there were six deaths, with no maternal deaths. We believe that these results confirm the value of phosphatidylglycerol in patients with premature rupture of the membranes, and that delay in patients from premature rupture of the membranes results in few infections and a significant decrease in the respiratory distress syndrome.
1978年7月1日至1981年6月30日期间，对214例胎膜早破患者前瞻性地研究了阴道羊水池评估的临床效用。对于妊娠36周前胎膜早破的患者，我们采用不干预策略。入院时及之后每日采集的阴道样本进行磷脂分析。患者因以下任何一种情况分娩：（1）存在磷脂酰甘油，（2）自然临产，或（3）败血症。167例患者最初无磷脂酰甘油。其中36例获得了磷脂酰甘油，且无一例发生呼吸窘迫综合征。8例患者因母亲出现败血症体征而分娩，但败血症母亲的所有婴儿均存活。49例患者的新生儿发生了呼吸窘迫综合征，其中6例死亡，无孕产妇死亡。我们认为这些结果证实了磷脂酰甘油在胎膜早破患者中的价值，并且胎膜早破患者的延迟处理导致感染较少且呼吸窘迫综合征显著减少。
