Milner R D, Herber S M
Arch Dis Child. 1983 Mar;58(3):195-7. doi: 10.1136/adc.58.3.195.
A retrospective analysis was made of 405 thyrotrophin-releasing hormone (TRH) stimulation tests on children who were successful applicants for growth hormone (GH) therapy in the UK between 1977 and 1981 inclusive. Thyroid-stimulating hormone (TSH) responses to TRH were divided into normal and those indicating pituitary or hypothalamic disease on the basis of criteria which eliminated variation in TSH assay between laboratories. Among children known to be hypothyroid 93% had abnormal TRH stimulation tests, but 35% of those children who were clinically euthyroid and who had normal serum thyroxin levels also had abnormal TSH responses to TRH. Abnormal TRH tests in the latter group were most common in euthyroid children who had GH deficiency with clearly defined aetiology and least common in those with idiopathic GH deficiency. Further work is required to clarify the interpretation of an abnormal TRH stimulation test in this group of children, but until this is done, such patients should be kept under regular review with respect to thyroid function.
对1977年至1981年（含）期间在英国成功申请生长激素（GH）治疗的儿童进行的405次促甲状腺激素释放激素（TRH）刺激试验进行了回顾性分析。根据消除实验室间促甲状腺激素（TSH）检测差异的标准，将TSH对TRH的反应分为正常反应以及提示垂体或下丘脑疾病的反应。在已知甲状腺功能减退的儿童中，93%的TRH刺激试验异常，但在临床甲状腺功能正常且血清甲状腺素水平正常的儿童中，35%的儿童TSH对TRH的反应也异常。后一组中TRH试验异常在病因明确的生长激素缺乏的甲状腺功能正常儿童中最为常见，而在特发性生长激素缺乏的儿童中最不常见。需要进一步开展工作以阐明该组儿童TRH刺激试验异常的解读，但在此之前，应对此类患者的甲状腺功能进行定期复查。
