Herber S M, Milner R D
Arch Dis Child. 1984 Jun;59(6):557-60. doi: 10.1136/adc.59.6.557.
Twenty nine (1.8%) of a national cohort of 1600 patients with growth hormone deficiency presented before the age of 2 years. Sixteen of the 29 presented before 6 months of age--11 with symptomatic hypoglycaemia, four with failure to thrive, and one with obesity. Hypoglycaemia was persistent and difficult to control until growth hormone treatment was started. Ten of the 11 hypoglycaemic patients had multiple pituitary hormone deficiencies compared with two of the remaining five. Thirteen children presented between 6 months and 2 years of age; 12 had failure to thrive and one had spontaneous hypoglycaemia. Twelve of the 29 were boys and all but one of these had microgenitalia . Growth hormone deficiency should be considered in the differential diagnosis of infants presenting with refractory hypoglycaemia and in boys with failure to thrive and microgenitalia .
在1600名生长激素缺乏的全国队列患者中，29名（1.8%）在2岁之前发病。这29名患者中有16名在6个月之前发病——11名有症状性低血糖，4名生长发育迟缓，1名肥胖。在开始生长激素治疗之前，低血糖持续且难以控制。11名低血糖患者中有10名存在多种垂体激素缺乏，而其余5名中只有2名存在这种情况。13名儿童在6个月至2岁之间发病；12名生长发育迟缓，1名有自发性低血糖。29名患者中有12名是男孩，除1名外，所有男孩都有小阴茎。对于出现难治性低血糖的婴儿以及生长发育迟缓和有小阴茎的男孩，在鉴别诊断时应考虑生长激素缺乏。
