Adriamycin and daunomycin induce interstrand DNA crosslinks in Hela S3 Cells.
作者信息
Konopa J
出版信息
Biochem Biophys Res Commun. 1983 Feb 10;110(3):819-26. doi: 10.1016/0006-291x(83)91035-5.
PMID:6404263
Abstract
By using a new mild procedure for detecting DNA crosslinks it has been shown that adriamycin and daunomycin are able to form interstrand DNA crosslinks in HeLa cells. This effect seems to be preceded by transformation of the parent antibiotics in the cell to active forms. In addition, interstrand DNA crosslinks formed by adriamycin and daunomycin were found to be temperature- and alkali-labile.
摘要
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