Targum S D, Rosen L N, DeLisi L E, Weinberger D R, Citrin C M
Biol Psychiatry. 1983 Mar;18(3):329-36.
Computerized tomograms (CT scans) and neuroendocrine challenges (TRH stimulation test and dexamethasone suppression test) were completed in 38 melancholic depressed hospitalized patients. There were no significant differences in ventricular size between delusional and nondelusional depressives. However, 5 of 20 delusional depressives (25%) in contrast to none of 18 nondelusional depressives had ventricular brain ratios greater than 2 standard deviations from the mean of 26 neurological controls. There were no demographic, clinical, or neuroendocrine differences between patients with enlarged ventricles and those with normal CT scans. Two of 5 patients with large ventricles were rehospitalized within the 1st year of ascertainment in contrast to 3 of the other 15 delusional depressed patients. The possible relevance of cerebral ventricular size for depressive disorder is discussed.
对38例住院的抑郁性抑郁症患者进行了计算机断层扫描（CT扫描）和神经内分泌激发试验（促甲状腺激素释放激素刺激试验和地塞米松抑制试验）。妄想型和非妄想型抑郁症患者的脑室大小无显著差异。然而，20例妄想型抑郁症患者中有5例（25%）的脑室脑比率高于26名神经学对照者均值的2个标准差，而18例非妄想型抑郁症患者中无一例如此。脑室扩大患者与CT扫描正常患者在人口统计学、临床或神经内分泌方面无差异。5例脑室大的患者中有2例在确诊后的第1年内再次住院，而其他15例妄想型抑郁症患者中有3例再次住院。本文讨论了脑室大小与抑郁症的可能相关性。
