Ingvar M, Lindvall O, Stenevi U
Brain Res. 1983 Mar 7;262(2):259-65. doi: 10.1016/0006-8993(83)91016-8.
Systemic administration of the dopamine (DA) receptor agonist apomorphine leads to a general increase in cerebral blood flow (CBF) as determined by the autoradiographic iodoantipyrine technique. The magnitude of the increase varies between different regions but shows no obvious relation to the density of either DA terminals or receptors. The circulatory response is much more prominent in the lateral than in the medial caudate-putamen. Apomorphine seems to increase CBF both via a change in metabolic rate and via stimulation of dilatory vascular receptors. In animals with unilateral 6-hydroxydopamine lesions of the ascending DA pathways apomorphine induces an augmented CBF response in some denervated structures, notably caudate-putamen and globus pallidus. It is concluded that this is partly due to stimulation of denervated supersensitive vascular receptors, suggesting a direct dopaminergic control of the blood vessels in these areas.
通过放射性碘安替比林自显影技术测定，多巴胺（DA）受体激动剂阿扑吗啡的全身给药会导致脑血流量（CBF）普遍增加。增加的幅度在不同区域有所不同，但与DA终末或受体的密度均无明显关系。循环反应在外侧尾状核-壳核比在内侧更为显著。阿扑吗啡似乎通过代谢率的变化和对血管舒张受体的刺激来增加CBF。在具有单侧6-羟基多巴胺损伤的上行DA通路的动物中，阿扑吗啡在一些去神经支配的结构中诱导增强的CBF反应，特别是尾状核-壳核和苍白球。得出的结论是，这部分是由于对去神经支配的超敏血管受体的刺激，提示这些区域血管存在直接的多巴胺能控制。
